|ACUTE ANGLE CLOSURE GLAUCOMA
SIGNS AND SYMPTOMS
The hallmark signs of angle closure include significantly elevated intraocular pressure, a closed angle upon gonioscopic evaluation, deep conjunctival and episcleral injection in a circumlimbal fashion, and a fixed, mid-dilated pupil. Upon slit-lamp examination, you may also see an edematous or "steamy" cornea and shallow anterior chamber.
Applanation tonometry may reveal IOP in the range of 30 to 60mm Hg, or even higher in some cases. Gonioscopy, which may prove difficult because of microcystic corneal edema, reveals no visible angle structures without indentation. There may be evidence of previous angle closure episodes in the form of peripheral anterior synechiae (PAS) in the fellow eye.
Another mechanism which may induce angle closure involves an abnormal configuration of the iris, the so-called "plateau iris syndrome." Patients with this presentation may boast a deep anterior chamber centrally; however, the iris demonstrates an unusual laxity, coming into close approximation with the angle peripherally. These patients may be prone to "angle crowding" and subsequent closure during physiologic or pharmacologic dilation. Other etiologies of angle closure without pupil block include neovascular membranes inducing PAS, anterior uveal displacement (such as in choroidal detachment) or, rarely, posterior segment inflammation or tumors.
Next, perform corneal compression with a gonioprism to aid in lowering the IOP by forcing aqueous into the trabeculum and temporarily opening the angle. It may be necessary to use topical glycerin to clear the cornea if there is significant edema. Perform tonometry every 15 minutes after initiating therapy.
If the patient does not achieve significant reduction in IOP after 45 minutes, administer an oral carbonic anhydrase inhibitor (acetazolamide 2 x 250mg tablets). You may also wish to use a hyperosmotic agent such as three to five ounces of oral glycerin or isosorbide over ice. Once the IOP is below 40mm Hg, instill pilocarpine 2% as well as prednisolone acetate 1% every 15 minutes to abate the attack and reopen the angle. It is safe to discontinue this regimen when the IOP is below 30mm Hg and the angle structures are again visible with gonioscopy. Maintain the patient on the following medications: pilocarpine 2% QID, prednisolone acetate 1% QID, timolol (or equivalent) 0.5% BID, and oral acetazolamide 500mg BID.
When the inflammation has diminished and the AC is quiet, refer the patient for a peripheral iridotomy. This provides a secondary outflow channel for aqueous, and commonly causes a permanent anatomical "deepening" of the anterior chamber.
Other Reports in This Section
Eyelids & Eyelashes | Conjunctiva & Sclera | Cornea
Uvea | Vitreous & Retina | Optic Nerve & Brain | Oculosystemic Disease
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